Zebrafish have the potential to accelerate and de-risk the drug discovery and development process by reducing attrition rates and lowering the development cost of producing new drugs. With a significant genetic similarity to humans and the presence of many vital organs including heart, brain and liver, the larval zebrafish is highly suitable for screening potential drug candidates for efficacy and safety effects.
Zebrafish can easily be manipulated through a range of technologies. At Summit we currently use the model in a number of different ways and some of these are listed below:
Phenotypic analysis of toxicological endpoints (wild type fish)
Neurobehavioral assessment (wild type fish)
Development of transgenic zebrafish lines
Green Fluorescent Protein labelling
Bone and cartilage staining.